So far, the leading cause of liver cancer is not known with certainty. However, hepatocellular carcinoma (primary liver cancer) tend to occur in the liver / liver is damaged due to birth defects, chronic infection caused by diseases such as hepatitis B and C, or alcohol abuse, hemochromatosis (contained too much iron in the liver) and cirrhosis. Over 50% of people diagnosed with primary liver cancer, liver cirrhosis have experienced. Those who suffer from a genetic condition called hemochromatosis are at increased risk.

Several cancer-causing substances associated with primary liver cancer, including: herbicides, aflatoxin (a type of fungus in wheat plants and crops), and certain chemicals such as vinyl chloride and arsenic. Alcohol abuse, in addition to smoking may also increase the risk of liver cancer.

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